IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Ratul Chowdhury; Matthew J. Grisewood; Veda Sheersh Boorla; Qiang Yan; Brian F. Pfleger; Costas D. Maranas

doi:10.1016/j.str.2020.08.003

IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Ratul Chowdhury, Matthew J. Grisewood, Veda Sheersh Boorla, Qiang Yan, Brian F. Pfleger, Costas D. Maranas

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.

Original language	English (US)
Pages (from-to)	1344-1357.e4
Journal	Structure
Volume	28
Issue number	12
DOIs	https://doi.org/10.1016/j.str.2020.08.003
State	Published - Dec 1 2020

All Science Journal Classification (ASJC) codes

Structural Biology
Molecular Biology

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10.1016/j.str.2020.08.003

Cite this

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title = "IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions",

abstract = "Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.",

author = "Ratul Chowdhury and Grisewood, {Matthew J.} and Boorla, {Veda Sheersh} and Qiang Yan and Pfleger, {Brian F.} and Maranas, {Costas D.}",

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AU - Boorla, Veda Sheersh

AU - Yan, Qiang

AU - Pfleger, Brian F.

AU - Maranas, Costas D.

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IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Abstract

All Science Journal Classification (ASJC) codes

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