IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Ratul Chowdhury; Matthew J. Grisewood; Veda Sheersh Boorla; Qiang Yan; Brian F. Pfleger; Costas D. Maranas

doi:10.1016/j.str.2020.08.003

IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Ratul Chowdhury
, Matthew J. Grisewood
, Veda Sheersh Boorla
, Qiang Yan
, Brian F. Pfleger
, Costas D. Maranas

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.

Original language	English (US)
Pages (from-to)	1344-1357.e4
Journal	Structure
Volume	28
Issue number	12
DOIs	https://doi.org/10.1016/j.str.2020.08.003
State	Published - Dec 1 2020

All Science Journal Classification (ASJC) codes

Structural Biology
Molecular Biology

Access to Document

10.1016/j.str.2020.08.003

Cite this

@article{ecb04e22a1b44991a316cea4d0b10b20,

title = "IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions",

abstract = "Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.",

author = "Ratul Chowdhury and Grisewood, \{Matthew J.\} and Boorla, \{Veda Sheersh\} and Qiang Yan and Pfleger, \{Brian F.\} and Maranas, \{Costas D.\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = dec,

day = "1",

doi = "10.1016/j.str.2020.08.003",

language = "English (US)",

volume = "28",

pages = "1344--1357.e4",

journal = "Structure",

issn = "0969-2126",

publisher = "Cell Press",

number = "12",

}

TY - JOUR

T1 - IPRO+/−

T2 - Computational Protein Design Tool Allowing for Insertions and Deletions

AU - Chowdhury, Ratul

AU - Grisewood, Matthew J.

AU - Boorla, Veda Sheersh

AU - Yan, Qiang

AU - Pfleger, Brian F.

AU - Maranas, Costas D.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.

AB - Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.

UR - https://www.scopus.com/pages/publications/85090484443

UR - https://www.scopus.com/pages/publications/85090484443#tab=citedBy

U2 - 10.1016/j.str.2020.08.003

DO - 10.1016/j.str.2020.08.003

M3 - Article

C2 - 32857964

AN - SCOPUS:85090484443

SN - 0969-2126

VL - 28

SP - 1344-1357.e4

JO - Structure

JF - Structure

IS - 12

ER -

IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this