IQ and variation in the number of fragile X CGG repeats: No association in a normal sample

J. K. Daniels; Michael J. Owen; Peter McGuffin; Lee Thompson; Douglas K. Detterman; Michael Chorney; Karen Chorney; Deborah Smith; Patricia Skuder; Sylvia Vignetti; Gerald E. McClearn; Robert Plomin

doi:10.1016/0160-2896(94)90052-3

IQ and variation in the number of fragile X CGG repeats: No association in a normal sample

J. K. Daniels
, Michael J. Owen
, Peter McGuffin
, Lee Thompson
, Douglas K. Detterman
, Michael Chorney
, Karen Chorney
, Deborah Smith
, Patricia Skuder
, Sylvia Vignetti
, Gerald E. McClearn
, Robert Plomin

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.

Original language	English (US)
Pages (from-to)	45-50
Number of pages	6
Journal	Intelligence
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0160-2896(94)90052-3
State	Published - 1994

All Science Journal Classification (ASJC) codes

Experimental and Cognitive Psychology
Developmental and Educational Psychology
Arts and Humanities (miscellaneous)

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10.1016/0160-2896(94)90052-3

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title = "IQ and variation in the number of fragile X CGG repeats: No association in a normal sample",

abstract = "Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.",

author = "Daniels, \{J. K.\} and Owen, \{Michael J.\} and Peter McGuffin and Lee Thompson and Detterman, \{Douglas K.\} and Michael Chorney and Karen Chorney and Deborah Smith and Patricia Skuder and Sylvia Vignetti and McClearn, \{Gerald E.\} and Robert Plomin",

year = "1994",

doi = "10.1016/0160-2896(94)90052-3",

language = "English (US)",

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T1 - IQ and variation in the number of fragile X CGG repeats

T2 - No association in a normal sample

AU - Daniels, J. K.

AU - Owen, Michael J.

AU - McGuffin, Peter

AU - Thompson, Lee

AU - Detterman, Douglas K.

AU - Chorney, Michael

AU - Chorney, Karen

AU - Smith, Deborah

AU - Skuder, Patricia

AU - Vignetti, Sylvia

AU - McClearn, Gerald E.

AU - Plomin, Robert

PY - 1994

Y1 - 1994

N2 - Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.

AB - Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.

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U2 - 10.1016/0160-2896(94)90052-3

DO - 10.1016/0160-2896(94)90052-3

M3 - Article

AN - SCOPUS:0040630350

SN - 0160-2896

VL - 19

SP - 45

EP - 50

JO - Intelligence

JF - Intelligence

IS - 1

ER -

IQ and variation in the number of fragile X CGG repeats: No association in a normal sample

Abstract

All Science Journal Classification (ASJC) codes

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