Iridium-Catalyzed ortho-C(sp2)-H Amidation of Benzaldehydes with Organic Azides

Delong Mu, Xinmou Wang, Gong Chen, Gang He

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


An iridium-catalyzed ortho-C(sp2)-H amidation reaction of benzaldehydes with organic azides has been developed. A catalytic amount of 3,5-di(trifluoromethyl)aniline was used to promote the Ir-catalyzed directed C-H amination reaction through a transient aldimine intermediate. This reaction tolerates a broad scope of benzaldehyde substrates and works well with a range of aryl- and alkylsulfonyl azides.

Original languageEnglish (US)
Pages (from-to)4497-4503
Number of pages7
JournalJournal of Organic Chemistry
Issue number8
StatePublished - Apr 21 2017

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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