Iridium-Catalyzed ortho-C(sp2)-H Amidation of Benzaldehydes with Organic Azides

Delong Mu; Xinmou Wang; Gong Chen; Gang He

doi:10.1021/acs.joc.7b00531

Iridium-Catalyzed ortho-C(sp²)-H Amidation of Benzaldehydes with Organic Azides

Delong Mu
, Xinmou Wang
, Gong Chen
, Gang He

Chemistry

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

An iridium-catalyzed ortho-C(sp²)-H amidation reaction of benzaldehydes with organic azides has been developed. A catalytic amount of 3,5-di(trifluoromethyl)aniline was used to promote the Ir-catalyzed directed C-H amination reaction through a transient aldimine intermediate. This reaction tolerates a broad scope of benzaldehyde substrates and works well with a range of aryl- and alkylsulfonyl azides.

Original language	English (US)
Pages (from-to)	4497-4503
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	82
Issue number	8
DOIs	https://doi.org/10.1021/acs.joc.7b00531
State	Published - Apr 21 2017

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/acs.joc.7b00531

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abstract = "An iridium-catalyzed ortho-C(sp2)-H amidation reaction of benzaldehydes with organic azides has been developed. A catalytic amount of 3,5-di(trifluoromethyl)aniline was used to promote the Ir-catalyzed directed C-H amination reaction through a transient aldimine intermediate. This reaction tolerates a broad scope of benzaldehyde substrates and works well with a range of aryl- and alkylsulfonyl azides.",

author = "Delong Mu and Xinmou Wang and Gong Chen and Gang He",

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AU - Mu, Delong

AU - Wang, Xinmou

AU - Chen, Gong

AU - He, Gang

PY - 2017/4/21

Y1 - 2017/4/21

N2 - An iridium-catalyzed ortho-C(sp2)-H amidation reaction of benzaldehydes with organic azides has been developed. A catalytic amount of 3,5-di(trifluoromethyl)aniline was used to promote the Ir-catalyzed directed C-H amination reaction through a transient aldimine intermediate. This reaction tolerates a broad scope of benzaldehyde substrates and works well with a range of aryl- and alkylsulfonyl azides.

AB - An iridium-catalyzed ortho-C(sp2)-H amidation reaction of benzaldehydes with organic azides has been developed. A catalytic amount of 3,5-di(trifluoromethyl)aniline was used to promote the Ir-catalyzed directed C-H amination reaction through a transient aldimine intermediate. This reaction tolerates a broad scope of benzaldehyde substrates and works well with a range of aryl- and alkylsulfonyl azides.

UR - https://www.scopus.com/pages/publications/85018462981

UR - https://www.scopus.com/pages/publications/85018462981#tab=citedBy

U2 - 10.1021/acs.joc.7b00531

DO - 10.1021/acs.joc.7b00531

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JF - Journal of Organic Chemistry

IS - 8

ER -

Iridium-Catalyzed ortho-C(sp²)-H Amidation of Benzaldehydes with Organic Azides

Abstract

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