Iron–sulfur cluster with double duty

Olga A. Esakova; Squire J. Booker

doi:10.1038/s41929-025-01386-7

Iron–sulfur cluster with double duty

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The radical S-adenosylmethionine (SAM) enzyme, AbmM, catalyses a replacement of the ring oxygen of a sugar with sulfur. However, how this reaction takes place is unknown. Now, an [Fe₄S₄] cluster is shown to have a dual role in catalysis. It functions in the reductive cleavage of SAM and is the donor of the appended sulfur atom.

Original language	English (US)
Pages (from-to)	758-759
Number of pages	2
Journal	Nature Catalysis
Volume	8
Issue number	8
DOIs	https://doi.org/10.1038/s41929-025-01386-7
State	Published - Aug 2025

All Science Journal Classification (ASJC) codes

Catalysis
Bioengineering
Biochemistry
Process Chemistry and Technology

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10.1038/s41929-025-01386-7

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title = "Iron–sulfur cluster with double duty",

abstract = "The radical S-adenosylmethionine (SAM) enzyme, AbmM, catalyses a replacement of the ring oxygen of a sugar with sulfur. However, how this reaction takes place is unknown. Now, an [Fe4S4] cluster is shown to have a dual role in catalysis. It functions in the reductive cleavage of SAM and is the donor of the appended sulfur atom.",

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AU - Esakova, Olga A.

AU - Booker, Squire J.

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Y1 - 2025/8

N2 - The radical S-adenosylmethionine (SAM) enzyme, AbmM, catalyses a replacement of the ring oxygen of a sugar with sulfur. However, how this reaction takes place is unknown. Now, an [Fe4S4] cluster is shown to have a dual role in catalysis. It functions in the reductive cleavage of SAM and is the donor of the appended sulfur atom.

AB - The radical S-adenosylmethionine (SAM) enzyme, AbmM, catalyses a replacement of the ring oxygen of a sugar with sulfur. However, how this reaction takes place is unknown. Now, an [Fe4S4] cluster is shown to have a dual role in catalysis. It functions in the reductive cleavage of SAM and is the donor of the appended sulfur atom.

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VL - 8

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JO - Nature Catalysis

JF - Nature Catalysis

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ER -

Iron–sulfur cluster with double duty

Abstract

All Science Journal Classification (ASJC) codes

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