Is acetylation the key to opening locked gates?

B. Franklin Pugh

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


Like certain protein kinases, some protein acetyltransferases such as p300 may use an inhibitory loop that can be regulated to limit the accessibility of substrates to its active site. The finding that autoacetylation of this loop activates the acetyltransferase provides the first evidence for an acetylation cascade analogous to protein kinase cascades.

Original languageEnglish (US)
Pages (from-to)298-300
Number of pages3
JournalNature Structural and Molecular Biology
Issue number4
StatePublished - Apr 2004

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


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