Is the tendon embryogenesis process resurrected during tendon healing?

John Ingraham, Randy Hauck, H. Paul Ehrlich

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


The process of embryonic tendon development, including the nature and purpose of collagen fibril segments, is reviewed. It is proposed that tendon fibrillogenesis of repair is related to the fibrillogenesis of tendon embryonic development. The assembly of collagen fibril segment units into longer fibers occurs on the surface of tendon fibroblasts in embryonic tendon development. The biochemist's view of tendon healing, whereby the spontaneous polymerization of tropocollagen monomers regenerates lost tendon collagen fibers, needs to be reconsidered. Furthermore, the importance of direct fibroblast involvement in collagen fiber reassembly during tendon healing needs to be studied in tendon intrinsic regenerative repair.

Original languageEnglish (US)
Pages (from-to)844-854
Number of pages11
JournalPlastic and reconstructive surgery
Issue number3
StatePublished - Sep 1 2003

All Science Journal Classification (ASJC) codes

  • Surgery


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