Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae)

Ken ichi Harada; Kenji Matsuura; Makoto Suzuki; Mariyo F. Watanabe; Shinshi Oishi; Andrew M. Dahlem; Val R. Beasley; Wayne W. Carmichael

doi:10.1016/0041-0101(90)90006-S

Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae)

Ken ichi Harada, Kenji Matsuura, Makoto Suzuki, Mariyo F. Watanabe, Shinshi Oishi, Andrew M. Dahlem, Val R. Beasley, Wayne W. Carmichael

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

K. Harada, K. Matsuura, M. Suzuki, M. F. Watanabe, S. Oishi, A. M. Dahlem, V. R. Beasley and W. W. Carmichael. Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae). Toxicon 28, 55-64, 1990.-Two structurally similar analogues of microcystins LR and RR, cyclic peptide hepatotoxins from Microcystis, were isolated by chromatographic methods. Although they have the same mol. wt and amino acid compositions as those of the parent toxins, they do not possess similar toxicities. Ultraviolet and ¹H-NMR spectral data for both components demonstrate clear structural difference of these cyclic peptides from the parent toxins, which are probably responsible for the marked decreases in their observed toxicities.

Original language	English (US)
Pages (from-to)	55-64
Number of pages	10
Journal	Toxicon
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0041-0101(90)90006-S
State	Published - 1990

All Science Journal Classification (ASJC) codes

Toxicology

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10.1016/0041-0101(90)90006-S

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@article{001251d8a07c4ec9bfd8677795f325f2,

title = "Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae)",

abstract = "K. Harada, K. Matsuura, M. Suzuki, M. F. Watanabe, S. Oishi, A. M. Dahlem, V. R. Beasley and W. W. Carmichael. Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae). Toxicon 28, 55-64, 1990.-Two structurally similar analogues of microcystins LR and RR, cyclic peptide hepatotoxins from Microcystis, were isolated by chromatographic methods. Although they have the same mol. wt and amino acid compositions as those of the parent toxins, they do not possess similar toxicities. Ultraviolet and 1H-NMR spectral data for both components demonstrate clear structural difference of these cyclic peptides from the parent toxins, which are probably responsible for the marked decreases in their observed toxicities.",

author = "Harada, \{Ken ichi\} and Kenji Matsuura and Makoto Suzuki and Watanabe, \{Mariyo F.\} and Shinshi Oishi and Dahlem, \{Andrew M.\} and Beasley, \{Val R.\} and Carmichael, \{Wayne W.\}",

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T1 - Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae)

AU - Harada, Ken ichi

AU - Matsuura, Kenji

AU - Suzuki, Makoto

AU - Watanabe, Mariyo F.

AU - Oishi, Shinshi

AU - Dahlem, Andrew M.

AU - Beasley, Val R.

AU - Carmichael, Wayne W.

PY - 1990

Y1 - 1990

N2 - K. Harada, K. Matsuura, M. Suzuki, M. F. Watanabe, S. Oishi, A. M. Dahlem, V. R. Beasley and W. W. Carmichael. Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae). Toxicon 28, 55-64, 1990.-Two structurally similar analogues of microcystins LR and RR, cyclic peptide hepatotoxins from Microcystis, were isolated by chromatographic methods. Although they have the same mol. wt and amino acid compositions as those of the parent toxins, they do not possess similar toxicities. Ultraviolet and 1H-NMR spectral data for both components demonstrate clear structural difference of these cyclic peptides from the parent toxins, which are probably responsible for the marked decreases in their observed toxicities.

AB - K. Harada, K. Matsuura, M. Suzuki, M. F. Watanabe, S. Oishi, A. M. Dahlem, V. R. Beasley and W. W. Carmichael. Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae). Toxicon 28, 55-64, 1990.-Two structurally similar analogues of microcystins LR and RR, cyclic peptide hepatotoxins from Microcystis, were isolated by chromatographic methods. Although they have the same mol. wt and amino acid compositions as those of the parent toxins, they do not possess similar toxicities. Ultraviolet and 1H-NMR spectral data for both components demonstrate clear structural difference of these cyclic peptides from the parent toxins, which are probably responsible for the marked decreases in their observed toxicities.

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VL - 28

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IS - 1

ER -

Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae)

Abstract

All Science Journal Classification (ASJC) codes

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