Isovolemic hemodilution increases retinal tissue oxygen tension

Kimberly A. Neely, J. Terry Ernest, Thomas K. Goldstick, Robert A. Linsenmeier, Jonathan Moss

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: Therapeutic isovolemic hemodilution has been reported to improve blood flow and oxygen delivery. Few reliable measurements have been made, however, showing the effect of hemodilution on tissue oxygen tension. Methods. We measured retinal oxygen tension during experimental isovolemic hemodilution in normal cats. Polarographic oxygen microelectrodes were placed in the vitreous humor within 100-200 μm of the retinal surface. Results: Tissue oxygen tension increased initially during isovolemic hemodilution to a maximum approximately 50% above baseline at approximately two thirds of the original hematocrit level. Hemodilution beyond this point to lower hematocrits caused a steady decline in tissue oxygen tension. Cardiac output measured in one cat undergoing isovolemic hemodilution increased as hematocrit was lowered, but the cardiac erythrocyte flux actually decreased steadily. Conclusion: The observed increase in tissue oxygen tension with hemodilution appears to be explained by a lesser reduction in capillary than in systemic hematocrit, coupled with an increased capillary blood now. The increase in tissue oxygen tension we observed could in part explain the clinically beneficial effects of hemodilution.

Original languageEnglish (US)
Pages (from-to)688-694
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number11
StatePublished - 1996

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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