Jaspamides H-L, new actin-targeting depsipeptides from the sponge Jaspis splendans

Fulvio Gala; Maria Valeria D'Auria; Simona De Marino; Valentina Sepe; Franco Zollo; Charles D. Smith; Jean E. Copper; Angela Zampella

doi:10.1016/j.tet.2008.05.037

Jaspamides H-L, new actin-targeting depsipeptides from the sponge Jaspis splendans

Fulvio Gala, Maria Valeria D'Auria, Simona De Marino, Valentina Sepe, Franco Zollo, Charles D. Smith, Jean E. Copper, Angela Zampella

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H-L (2-5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

Original language	English (US)
Pages (from-to)	7127-7130
Number of pages	4
Journal	Tetrahedron
Volume	64
Issue number	30-31
DOIs	https://doi.org/10.1016/j.tet.2008.05.037
State	Published - Jul 21 2008

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2008.05.037

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abstract = "Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H-L (2-5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.",

author = "Fulvio Gala and D'Auria, {Maria Valeria} and {De Marino}, Simona and Valentina Sepe and Franco Zollo and Smith, {Charles D.} and Copper, {Jean E.} and Angela Zampella",

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AU - Gala, Fulvio

AU - D'Auria, Maria Valeria

AU - De Marino, Simona

AU - Sepe, Valentina

AU - Zollo, Franco

AU - Smith, Charles D.

AU - Copper, Jean E.

AU - Zampella, Angela

PY - 2008/7/21

Y1 - 2008/7/21

N2 - Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H-L (2-5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

AB - Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H-L (2-5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

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DO - 10.1016/j.tet.2008.05.037

M3 - Article

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JO - Tetrahedron

JF - Tetrahedron

IS - 30-31

ER -

Jaspamides H-L, new actin-targeting depsipeptides from the sponge Jaspis splendans

Abstract

All Science Journal Classification (ASJC) codes

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