TY - JOUR
T1 - JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex
AU - Jin, Ye
AU - Wang, Yanming
AU - Johansen, Jørgen
AU - Johansen, Kristen M.
PY - 2000/5/29
Y1 - 2000/5/29
N2 - JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL- 1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.
AB - JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL- 1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.
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U2 - 10.1083/jcb.149.5.1005
DO - 10.1083/jcb.149.5.1005
M3 - Article
C2 - 10831604
AN - SCOPUS:0034729334
SN - 0021-9525
VL - 149
SP - 1005
EP - 1010
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 5
ER -