Abstract
JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL- 1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1005-1010 |
| Number of pages | 6 |
| Journal | Journal of Cell Biology |
| Volume | 149 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 29 2000 |
All Science Journal Classification (ASJC) codes
- Cell Biology
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