@article{afbc585d0a2743a8b20b5b02251b0874,
title = "JIL-1: A novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila",
abstract = "We have cloned and characterized JIL-1, a novel tandem kinase in Drosophila that associates with the chromosomes throughout the cell cycle. Antibody staining and live imaging of JIL-1-GFP transgenic flies show that JIL-1 localizes to the gene-rich interband regions of larval polytene chromosomes and is upregulated almost 2-fold on the hypertranscribed male X chromosome compared to autosomes. Phylogenetic analysis suggests that JIL-1 together with human MSKs defines a separate family of tandem kinases. That JIL-1 is a functional kinase was demonstrated by autophosphorylation and phosphorylation of histone H3 in vitro. Based on these findings, we propose that JIL-1 may play a role in transcriptional control potentially by regulating chromatin structure.",
author = "Ye Jin and Yanming Wang and Walker, {Diana L.} and Hao Dong and Cherice Conley and J{\o}rgen Johansen and Johansen, {Kristen M.}",
note = "Funding Information: We wish to thank Drs. Linda Ambrosio and Jack Girton for advice, discussion, and for providing the pCaSpeR vectors and the w; Δ2-3/TM2 Ubx stock; Drs. Peter Tolias and Kai Zinn for their generous gift of cDNA libraries; and Dr. Kathy Matthews and the Bloomington Drosophila Stock Center for providing the Df(3L)vin5 stock. We also wish to thank Ms. Anna Yeung for expert technical assistance and Ms. Virginia Lephart for maintenance of fly stocks. This work was supported by NSF Grant MCB-9600587, by NSF Training Grant DIR9113595 graduate (D. L. W.) and undergraduate (C. C.) fellowships, and by Fung and Stadler Awards (Y. J.). This is Journal Paper Number 18429 of the Iowa Agriculture and Home Economics Experiment Station, Ames, Iowa, Project Number 3429, and is supported by Hatch Act and State of Iowa funds. ",
year = "1999",
month = jul,
doi = "10.1016/S1097-2765(00)80195-1",
language = "English (US)",
volume = "4",
pages = "129--135",
journal = "Molecular cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "1",
}