TY - GEN
T1 - Kalman filter tracking of intracellular neuronal voltage and current
AU - Wei, Yina
AU - Ullah, Ghanim
AU - Parekh, Ruchi
AU - Ziburkus, Jokubas
AU - Schiff, Steven
PY - 2011
Y1 - 2011
N2 - The nervous system encodes and processes information with the activities of neurons. The response of a single neuron is complex and depends on the interactions between its previous state, its intrinsic properties, and the stimuli it receives. Experimentally, we utilize the patch clamp technique to monitor neural membrane voltages, but the underlying stimuli, including the external current or synaptic current from other neurons, cannot be fully observed. In this paper, we used computational models as an alternative to tackle these challenges. We employed an ensemble Kalman filter to reconstruct unobserved intracellular variables and parameters only from measured membrane potentials in a CA1 pyramidal neuron model that follows Hodgkin-Huxley dynamics. We found that the tracking of intracellular neuronal voltage and current was close to their true values whether the observations are from model generated data or real experimental data. In addition, we retrieved the experimentally inaccessible dynamics of the neuron, such as the changes of sodium and potassium gating variables, which helps to understand their roles in generating action potentials. Our study provides a powerful framework for observing dynamics underlying neural activity and seeking better real-time neuronal control.
AB - The nervous system encodes and processes information with the activities of neurons. The response of a single neuron is complex and depends on the interactions between its previous state, its intrinsic properties, and the stimuli it receives. Experimentally, we utilize the patch clamp technique to monitor neural membrane voltages, but the underlying stimuli, including the external current or synaptic current from other neurons, cannot be fully observed. In this paper, we used computational models as an alternative to tackle these challenges. We employed an ensemble Kalman filter to reconstruct unobserved intracellular variables and parameters only from measured membrane potentials in a CA1 pyramidal neuron model that follows Hodgkin-Huxley dynamics. We found that the tracking of intracellular neuronal voltage and current was close to their true values whether the observations are from model generated data or real experimental data. In addition, we retrieved the experimentally inaccessible dynamics of the neuron, such as the changes of sodium and potassium gating variables, which helps to understand their roles in generating action potentials. Our study provides a powerful framework for observing dynamics underlying neural activity and seeking better real-time neuronal control.
UR - http://www.scopus.com/inward/record.url?scp=84860677279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860677279&partnerID=8YFLogxK
U2 - 10.1109/CDC.2011.6161358
DO - 10.1109/CDC.2011.6161358
M3 - Conference contribution
AN - SCOPUS:84860677279
SN - 9781612848006
T3 - Proceedings of the IEEE Conference on Decision and Control
SP - 5844
EP - 5849
BT - 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011
Y2 - 12 December 2011 through 15 December 2011
ER -