Keratins Are Going Nuclear

Ryan P. Hobbs; Justin T. Jacob; Pierre A. Coulombe

doi:10.1016/j.devcel.2016.07.022

Keratins Are Going Nuclear

Ryan P. Hobbs, Justin T. Jacob, Pierre A. Coulombe

Research output: Contribution to journal › Comment/debate › peer-review

45 Scopus citations

Abstract

Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

Original language	English (US)
Pages (from-to)	227-233
Number of pages	7
Journal	Developmental Cell
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2016.07.022
State	Published - Aug 8 2016

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2016.07.022

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@article{46fe7b1884d4448995e7303eaa63a3d2,

title = "Keratins Are Going Nuclear",

abstract = "Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.",

author = "Hobbs, {Ryan P.} and Jacob, {Justin T.} and Coulombe, {Pierre A.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = aug,

day = "8",

doi = "10.1016/j.devcel.2016.07.022",

language = "English (US)",

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pages = "227--233",

journal = "Developmental Cell",

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T1 - Keratins Are Going Nuclear

AU - Hobbs, Ryan P.

AU - Jacob, Justin T.

AU - Coulombe, Pierre A.

PY - 2016/8/8

Y1 - 2016/8/8

N2 - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

AB - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

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U2 - 10.1016/j.devcel.2016.07.022

DO - 10.1016/j.devcel.2016.07.022

M3 - Comment/debate

C2 - 27505414

AN - SCOPUS:84989841260

SN - 1534-5807

VL - 38

SP - 227

EP - 233

JO - Developmental Cell

JF - Developmental Cell

IS - 3

ER -

Keratins Are Going Nuclear

Abstract

All Science Journal Classification (ASJC) codes

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