Killing two birds with one RKIP

Reema Goel, Joseph J. Baldassare

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations


Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.

Original languageEnglish (US)
Pages (from-to)91-92
Number of pages2
JournalTrends in Endocrinology and Metabolism
Issue number3
StatePublished - Apr 2004

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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