Killing two birds with one RKIP

Reema Goel; Joseph J. Baldassare

doi:10.1016/j.tem.2004.02.004

Killing two birds with one RKIP

Reema Goel
, Joseph J. Baldassare

Department of Public Health Sciences

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.

Original language	English (US)
Pages (from-to)	91-92
Number of pages	2
Journal	Trends in Endocrinology and Metabolism
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.tem.2004.02.004
State	Published - Apr 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2004.02.004

Cite this

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title = "Killing two birds with one RKIP",

abstract = "Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.",

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journal = "Trends in Endocrinology and Metabolism",

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T1 - Killing two birds with one RKIP

AU - Goel, Reema

AU - Baldassare, Joseph J.

PY - 2004/4

Y1 - 2004/4

N2 - Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.

AB - Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.

UR - https://www.scopus.com/pages/publications/1842418691

UR - https://www.scopus.com/pages/publications/1842418691#tab=citedBy

U2 - 10.1016/j.tem.2004.02.004

DO - 10.1016/j.tem.2004.02.004

M3 - Short survey

C2 - 15146872

AN - SCOPUS:1842418691

SN - 1043-2760

VL - 15

SP - 91

EP - 92

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 3

ER -

Killing two birds with one RKIP

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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