Kinetic parameters for plasma beta-endorphin in lean and obese Zucker rats

D. Rodd; P. A. Farrell; A. L. Caston; M. H. Green

doi:10.1016/0196-9781(91)90024-J

Kinetic parameters for plasma beta-endorphin in lean and obese Zucker rats

D. Rodd, P. A. Farrell, A. L. Caston, M. H. Green

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

To determine plasma clearance kinetics for beta-endorphin (BE) by empirical compartmental analysis, a bolus of radioactive labeled ¹²⁵I-BE was rapidly injected into a carotid artery catheter of unanesthetized lean (L) and obese (O) Zucker rats. The plasma disappearance of ¹²⁵I was followed over a 3-h period. A 3-component exponential equation provided the best fit for plasma data. Plasma transit times were very short (10 s); however, plasma fractional catabolic rate was much slower. Plasma mean residence time was similar for both groups (50 min) as was recycle time (1.3 min). These data suggest that BE plasma disappearance kinetics are similar in L and O rats.

Original language	English (US)
Pages (from-to)	345-349
Number of pages	5
Journal	Peptides
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(91)90024-J
State	Published - 1991

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(91)90024-J

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title = "Kinetic parameters for plasma beta-endorphin in lean and obese Zucker rats",

abstract = "To determine plasma clearance kinetics for beta-endorphin (BE) by empirical compartmental analysis, a bolus of radioactive labeled 125I-BE was rapidly injected into a carotid artery catheter of unanesthetized lean (L) and obese (O) Zucker rats. The plasma disappearance of 125I was followed over a 3-h period. A 3-component exponential equation provided the best fit for plasma data. Plasma transit times were very short (10 s); however, plasma fractional catabolic rate was much slower. Plasma mean residence time was similar for both groups (50 min) as was recycle time (1.3 min). These data suggest that BE plasma disappearance kinetics are similar in L and O rats.",

author = "D. Rodd and Farrell, {P. A.} and Caston, {A. L.} and Green, {M. H.}",

note = "Funding Information: This study was supported by the College of Health and Human Development Research Program, Pennsylvania State University, University Park, PA 16802.",

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T1 - Kinetic parameters for plasma beta-endorphin in lean and obese Zucker rats

AU - Rodd, D.

AU - Farrell, P. A.

AU - Caston, A. L.

AU - Green, M. H.

N1 - Funding Information: This study was supported by the College of Health and Human Development Research Program, Pennsylvania State University, University Park, PA 16802.

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Y1 - 1991

N2 - To determine plasma clearance kinetics for beta-endorphin (BE) by empirical compartmental analysis, a bolus of radioactive labeled 125I-BE was rapidly injected into a carotid artery catheter of unanesthetized lean (L) and obese (O) Zucker rats. The plasma disappearance of 125I was followed over a 3-h period. A 3-component exponential equation provided the best fit for plasma data. Plasma transit times were very short (10 s); however, plasma fractional catabolic rate was much slower. Plasma mean residence time was similar for both groups (50 min) as was recycle time (1.3 min). These data suggest that BE plasma disappearance kinetics are similar in L and O rats.

AB - To determine plasma clearance kinetics for beta-endorphin (BE) by empirical compartmental analysis, a bolus of radioactive labeled 125I-BE was rapidly injected into a carotid artery catheter of unanesthetized lean (L) and obese (O) Zucker rats. The plasma disappearance of 125I was followed over a 3-h period. A 3-component exponential equation provided the best fit for plasma data. Plasma transit times were very short (10 s); however, plasma fractional catabolic rate was much slower. Plasma mean residence time was similar for both groups (50 min) as was recycle time (1.3 min). These data suggest that BE plasma disappearance kinetics are similar in L and O rats.

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Kinetic parameters for plasma beta-endorphin in lean and obese Zucker rats

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