Kupffer cells play a major role in insulin-mediated hepatic glucose uptake in vivo

Zoltán Spolarics, Aurél Ottlakán, Charles H. Lang, John J. Spitzer

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5 Scopus citations


The effect of insulin on the in vivo glucose utilization by different hepatic cells was investigated using the euglycemic, hyperinsulinemic clamp, combined with the 2-deoxyglucose tracer technique. Rats were infused with insulin at a rate of 2.8 or 9.0 mU/min/kg for 220 min, resulting in plasma concentrations of the hormone of about 80 μU/ml and 340 μU/ml, respectively. Glucose use by the whole liver was elevated by more than 200 % following insulin. However, glucose uptake by the parenchymal cells was only elevated by 50-60 %. By contrast nonparenchymal cells were more responsive to insulin. Glucose uptake by endothelial cells was increased 100 % and Kupffer cells displayed the most marked response to insulin showing a 3- to 6-fold increase in glucose uptake. These data indicate that the sinusoidal nonparenchymal cells are the major sites of the insulin-mediated increased glucose utilization by the liver.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Jul 15 1992

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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