TY - JOUR
T1 - Lack of evidence for perfluorodecanoyl‐ or perfluorooctanoyl‐coenzyme a formation in male and female rats
AU - Kuslikis, Benedict I.
AU - Vanden Heuvel, John P.
AU - Peterson, Richard E.
PY - 1992
Y1 - 1992
N2 - Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a COA conjugate of clofibric acid, no corresponding COA derivative could be found for either PFDA or PFOA.
AB - Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a COA conjugate of clofibric acid, no corresponding COA derivative could be found for either PFDA or PFOA.
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U2 - 10.1002/jbt.2570070106
DO - 10.1002/jbt.2570070106
M3 - Article
C2 - 1588571
AN - SCOPUS:0026832239
SN - 0887-2082
VL - 7
SP - 25
EP - 29
JO - Journal of Biochemical Toxicology
JF - Journal of Biochemical Toxicology
IS - 1
ER -