Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine

I. Celine Hanson; Tracy A. Antonelli; Rhoda S. Sperling; James M. Oleske; Ellen Cooper; Mary Culnane; Mary Glenn Fowler; Leslie A. Kalish; Sophia S. Lee; George McSherry; Lynne Mofenson; David E. Shapiro

doi:10.1097/00042560-199904150-00008

Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine

I. Celine Hanson
, Tracy A. Antonelli
, Rhoda S. Sperling
, James M. Oleske
, Ellen Cooper
, Mary Culnane
, Mary Glenn Fowler
, Leslie A. Kalish
, Sophia S. Lee
, George McSherry
, Lynne Mofenson
, David E. Shapiro

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Zidovudine (ZDV) therapy during pregnancy and to the neonate reduced perinatal HIV transmission by nearly 70% in Pediatric AIDS Clinical Trials Group (PACTG) protocol 076. ZDV has been reported as positive in several in vitro carcinogenicity screening tests. We evaluated the short-term risk for tumors in 727 children with known ZDV exposure enrolled into the PACTG 076/219 and the Women and Infants Transmission Study (WITS). ZDV exposure in utero (antepartum) occurred in 97% and 99% of infants in PACTG 076/219 or WITS, respectively. Mean follow-up was 38.3 months with 366.9 person years follow-up for PACTG 076/219 and 14.5 months with 743.7 person years follow- up for WITS. No tumors of any nature were observed; relative risk was 0 (95% confidence interval [CI], 0-17.6). These data are reassuring regarding the short-term lack of tumors for ZDV-exposed infants observed to date. Longitudinal, standardized follow-up for infants with in utero antiretroviral exposure is necessary to assess long-term carcinogenicity.

Original language	English (US)
Pages (from-to)	463-467
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1097/00042560-199904150-00008
State	Published - Apr 15 1999

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00042560-199904150-00008

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Hanson, I. C., Antonelli, T. A., Sperling, R. S., Oleske, J. M., Cooper, E., Culnane, M., Fowler, M. G., Kalish, L. A., Lee, S. S., McSherry, G., Mofenson, L., & Shapiro, D. E. (1999). Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 20(5), 463-467. https://doi.org/10.1097/00042560-199904150-00008

@article{255c537384bb4b5db4ece7598127bb06,

title = "Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine",

abstract = "Zidovudine (ZDV) therapy during pregnancy and to the neonate reduced perinatal HIV transmission by nearly 70\% in Pediatric AIDS Clinical Trials Group (PACTG) protocol 076. ZDV has been reported as positive in several in vitro carcinogenicity screening tests. We evaluated the short-term risk for tumors in 727 children with known ZDV exposure enrolled into the PACTG 076/219 and the Women and Infants Transmission Study (WITS). ZDV exposure in utero (antepartum) occurred in 97\% and 99\% of infants in PACTG 076/219 or WITS, respectively. Mean follow-up was 38.3 months with 366.9 person years follow-up for PACTG 076/219 and 14.5 months with 743.7 person years follow- up for WITS. No tumors of any nature were observed; relative risk was 0 (95\% confidence interval [CI], 0-17.6). These data are reassuring regarding the short-term lack of tumors for ZDV-exposed infants observed to date. Longitudinal, standardized follow-up for infants with in utero antiretroviral exposure is necessary to assess long-term carcinogenicity.",

author = "Hanson, \{I. Celine\} and Antonelli, \{Tracy A.\} and Sperling, \{Rhoda S.\} and Oleske, \{James M.\} and Ellen Cooper and Mary Culnane and Fowler, \{Mary Glenn\} and Kalish, \{Leslie A.\} and Lee, \{Sophia S.\} and George McSherry and Lynne Mofenson and Shapiro, \{David E.\}",

year = "1999",

month = apr,

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doi = "10.1097/00042560-199904150-00008",

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Hanson, IC, Antonelli, TA, Sperling, RS, Oleske, JM, Cooper, E, Culnane, M, Fowler, MG, Kalish, LA, Lee, SS, McSherry, G, Mofenson, L & Shapiro, DE 1999, 'Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 20, no. 5, pp. 463-467. https://doi.org/10.1097/00042560-199904150-00008

TY - JOUR

T1 - Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine

AU - Hanson, I. Celine

AU - Antonelli, Tracy A.

AU - Sperling, Rhoda S.

AU - Oleske, James M.

AU - Cooper, Ellen

AU - Culnane, Mary

AU - Fowler, Mary Glenn

AU - Kalish, Leslie A.

AU - Lee, Sophia S.

AU - McSherry, George

AU - Mofenson, Lynne

AU - Shapiro, David E.

PY - 1999/4/15

Y1 - 1999/4/15

N2 - Zidovudine (ZDV) therapy during pregnancy and to the neonate reduced perinatal HIV transmission by nearly 70% in Pediatric AIDS Clinical Trials Group (PACTG) protocol 076. ZDV has been reported as positive in several in vitro carcinogenicity screening tests. We evaluated the short-term risk for tumors in 727 children with known ZDV exposure enrolled into the PACTG 076/219 and the Women and Infants Transmission Study (WITS). ZDV exposure in utero (antepartum) occurred in 97% and 99% of infants in PACTG 076/219 or WITS, respectively. Mean follow-up was 38.3 months with 366.9 person years follow-up for PACTG 076/219 and 14.5 months with 743.7 person years follow- up for WITS. No tumors of any nature were observed; relative risk was 0 (95% confidence interval [CI], 0-17.6). These data are reassuring regarding the short-term lack of tumors for ZDV-exposed infants observed to date. Longitudinal, standardized follow-up for infants with in utero antiretroviral exposure is necessary to assess long-term carcinogenicity.

AB - Zidovudine (ZDV) therapy during pregnancy and to the neonate reduced perinatal HIV transmission by nearly 70% in Pediatric AIDS Clinical Trials Group (PACTG) protocol 076. ZDV has been reported as positive in several in vitro carcinogenicity screening tests. We evaluated the short-term risk for tumors in 727 children with known ZDV exposure enrolled into the PACTG 076/219 and the Women and Infants Transmission Study (WITS). ZDV exposure in utero (antepartum) occurred in 97% and 99% of infants in PACTG 076/219 or WITS, respectively. Mean follow-up was 38.3 months with 366.9 person years follow-up for PACTG 076/219 and 14.5 months with 743.7 person years follow- up for WITS. No tumors of any nature were observed; relative risk was 0 (95% confidence interval [CI], 0-17.6). These data are reassuring regarding the short-term lack of tumors for ZDV-exposed infants observed to date. Longitudinal, standardized follow-up for infants with in utero antiretroviral exposure is necessary to assess long-term carcinogenicity.

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JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

IS - 5

ER -

Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine

Abstract

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