LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer

Tiansuo Zhao; He Ren; Jing Li; Jing Chen; Huan Zhang; Wen Xin; Yan Sun; Lei Sun; Yongwei Yang; Junwei Sun; Xiuchao Wang; Song Gao; Chongbiao Huang; Huafeng Zhang; Shengyu Yang; Jihui Hao

doi:10.1158/0008-5472.CAN-14-2040

LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer

Tiansuo Zhao, He Ren, Jing Li, Jing Chen, Huan Zhang, Wen Xin, Yan Sun, Lei Sun, Yongwei Yang, Junwei Sun, Xiuchao Wang, Song Gao, Chongbiao Huang, Huafeng Zhang, Shengyu Yang, Jihui Hao

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Abstract

LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells.Here,wereport that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF1α through direct binding to a hypoxia response element in the LASP1 promoter. HIF1α stimulated LASP1 expression in PDAC cells in vitro and mouse tumor xenografts in vivo. Clinically, LASP1 overexpression in PDAC patient specimens was associated significantly with lymph node metastasis and overall survival. Overall, our results defined LASP1 as a direct target gene for HIF1α upregulation that is critical for metastatic progression of PDAC.

Original language	English (US)
Pages (from-to)	111-119
Number of pages	9
Journal	Cancer Research
Volume	75
Issue number	1
DOIs	https://doi.org/10.1158/0008-5472.CAN-14-2040
State	Published - Jan 1 2015

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/0008-5472.CAN-14-2040

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title = "LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer",

abstract = "LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells.Here,wereport that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF1α through direct binding to a hypoxia response element in the LASP1 promoter. HIF1α stimulated LASP1 expression in PDAC cells in vitro and mouse tumor xenografts in vivo. Clinically, LASP1 overexpression in PDAC patient specimens was associated significantly with lymph node metastasis and overall survival. Overall, our results defined LASP1 as a direct target gene for HIF1α upregulation that is critical for metastatic progression of PDAC.",

author = "Tiansuo Zhao and He Ren and Jing Li and Jing Chen and Huan Zhang and Wen Xin and Yan Sun and Lei Sun and Yongwei Yang and Junwei Sun and Xiuchao Wang and Song Gao and Chongbiao Huang and Huafeng Zhang and Shengyu Yang and Jihui Hao",

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doi = "10.1158/0008-5472.CAN-14-2040",

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T1 - LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer

AU - Zhao, Tiansuo

AU - Ren, He

AU - Li, Jing

AU - Chen, Jing

AU - Zhang, Huan

AU - Xin, Wen

AU - Sun, Yan

AU - Sun, Lei

AU - Yang, Yongwei

AU - Sun, Junwei

AU - Wang, Xiuchao

AU - Gao, Song

AU - Huang, Chongbiao

AU - Zhang, Huafeng

AU - Yang, Shengyu

AU - Hao, Jihui

PY - 2015/1/1

Y1 - 2015/1/1

N2 - LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells.Here,wereport that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF1α through direct binding to a hypoxia response element in the LASP1 promoter. HIF1α stimulated LASP1 expression in PDAC cells in vitro and mouse tumor xenografts in vivo. Clinically, LASP1 overexpression in PDAC patient specimens was associated significantly with lymph node metastasis and overall survival. Overall, our results defined LASP1 as a direct target gene for HIF1α upregulation that is critical for metastatic progression of PDAC.

AB - LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells.Here,wereport that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF1α through direct binding to a hypoxia response element in the LASP1 promoter. HIF1α stimulated LASP1 expression in PDAC cells in vitro and mouse tumor xenografts in vivo. Clinically, LASP1 overexpression in PDAC patient specimens was associated significantly with lymph node metastasis and overall survival. Overall, our results defined LASP1 as a direct target gene for HIF1α upregulation that is critical for metastatic progression of PDAC.

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SN - 0008-5472

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SP - 111

EP - 119

JO - Cancer Research

JF - Cancer Research

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LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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