Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6

C. S. Rosenfeld; W. B. Rybka; D. Weinbaum; D. R. Carrigan; K. K. Knox; D. F. Andrews; R. K. Shadduck

Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6

C. S. Rosenfeld, W. B. Rybka, D. Weinbaum, D. R. Carrigan, K. K. Knox, D. F. Andrews, R. K. Shadduck

Research output: Contribution to journal › Article › peer-review

Abstract

Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.

Original language	English (US)
Pages (from-to)	626-629
Number of pages	4
Journal	Experimental Hematology
Volume	23
Issue number	7
State	Published - Jan 1 1995

All Science Journal Classification (ASJC) codes

Molecular Biology
Hematology
Genetics
Cell Biology
Cancer Research

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Cite this

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title = "Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6",

abstract = "Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.",

author = "Rosenfeld, {C. S.} and Rybka, {W. B.} and D. Weinbaum and Carrigan, {D. R.} and Knox, {K. K.} and Andrews, {D. F.} and Shadduck, {R. K.}",

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T1 - Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6

AU - Rosenfeld, C. S.

AU - Rybka, W. B.

AU - Weinbaum, D.

AU - Carrigan, D. R.

AU - Knox, K. K.

AU - Andrews, D. F.

AU - Shadduck, R. K.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.

AB - Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.

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Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6

Abstract

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