Latent transforming growth factor beta binding protein 4: A regulator of mitochondrial function in acute kidney injury

Kit Neikirk, Adaku C. Ume, Praveena Prasad, Andrea G. Marshall, Jananie Rockwood, Tara Yesomi Wenegieme, Kelia E. McMichael, Melanie R. McReynolds, Clintoria R. Williams, Antentor Hinton

Research output: Contribution to journalShort surveypeer-review

Abstract

Recently, latent transforming growth factor beta binding protein 4 (LTBP4) was implicated in the pathogenesis of renal damage through its modulation of mitochondrial dynamics. The seminal article written by Su et al. entitled “LTBP4 (Latent Transforming Growth Factor Beta Binding Protein 4) Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts” uncovers LTBP4's renoprotective role against acute kidney injury via modulating mitochondrial dynamics. Recently, LTBP4 has emerged as a driver in the mitochondrial-dependent modulation of age-related organ pathologies. This article aims to expand our understanding of LTBP4's diverse roles in these diseases in the context of these recent findings.

Original languageEnglish (US)
Article numbere14019
JournalAging cell
Volume22
Issue number12
DOIs
StatePublished - Dec 2023

All Science Journal Classification (ASJC) codes

  • Aging
  • Cell Biology

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