(Figure presented.) Neutrophils induce ferroptosis in glioblastoma, thus promoting necrosis during early tumor progression but the underlying mechanisms remain unclear. Here, neutrophil engulfment by tumor cells is uncovered as a critical step facilitating the transfer of neutrophilic granules and tumor cell ferroptosis. Statins inhibit neutrophil-induced tumor cell death by blocking neutrophilic granule transfer. Integrin-mediated cell adhesion is required for tumor cell killing by neutrophils. Neutrophils are engulfed by tumor cells before releasing myeloperoxidase-containing contents into tumor cells. LC3-associated phagocytosis is responsible for neutrophil internalization by tumor cells. Myeloperoxidase inhibition or Vps34 depletion reduces necrosis in glioblastomas and prolongs survival of tumor-bearing mice.

Original languageEnglish (US)
Pages (from-to)2582-2605
Number of pages24
JournalEMBO Journal
Issue number13
StatePublished - Jul 1 2024

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

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