Left atrial appendage occlusion: A critical appraisal updated with recent evidence

John M. Mandrola; Andrew J. Foy

doi:10.1097/HCO.0000000000000698

Left atrial appendage occlusion: A critical appraisal updated with recent evidence

John M. Mandrola, Andrew J. Foy

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of reviewTo allow readers to fully appreciate the uncertainties with this novel yet invasive approach to stroke prevention.Recent findingsPercutaneous left atrial (LA) appendage occlusion has emerged as potential nonpharmacologic means to prevent stroke and systemic embolism in patients with atrial fibrillation. Yet the evidence underpinning this new technology is not definitive.SummaryIn this review, we consider the internal and external validity of the regulatory trials, pathophysiologic basis for LA appendage occlusion and clinical tradeoffs of the procedure.

Original language	English (US)
Pages (from-to)	30-34
Number of pages	5
Journal	Current Opinion in Cardiology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1097/HCO.0000000000000698
State	Published - Jan 1 2020

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1097/HCO.0000000000000698

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title = "Left atrial appendage occlusion: A critical appraisal updated with recent evidence",

abstract = "Purpose of reviewTo allow readers to fully appreciate the uncertainties with this novel yet invasive approach to stroke prevention.Recent findingsPercutaneous left atrial (LA) appendage occlusion has emerged as potential nonpharmacologic means to prevent stroke and systemic embolism in patients with atrial fibrillation. Yet the evidence underpinning this new technology is not definitive.SummaryIn this review, we consider the internal and external validity of the regulatory trials, pathophysiologic basis for LA appendage occlusion and clinical tradeoffs of the procedure.",

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N2 - Purpose of reviewTo allow readers to fully appreciate the uncertainties with this novel yet invasive approach to stroke prevention.Recent findingsPercutaneous left atrial (LA) appendage occlusion has emerged as potential nonpharmacologic means to prevent stroke and systemic embolism in patients with atrial fibrillation. Yet the evidence underpinning this new technology is not definitive.SummaryIn this review, we consider the internal and external validity of the regulatory trials, pathophysiologic basis for LA appendage occlusion and clinical tradeoffs of the procedure.

AB - Purpose of reviewTo allow readers to fully appreciate the uncertainties with this novel yet invasive approach to stroke prevention.Recent findingsPercutaneous left atrial (LA) appendage occlusion has emerged as potential nonpharmacologic means to prevent stroke and systemic embolism in patients with atrial fibrillation. Yet the evidence underpinning this new technology is not definitive.SummaryIn this review, we consider the internal and external validity of the regulatory trials, pathophysiologic basis for LA appendage occlusion and clinical tradeoffs of the procedure.

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Left atrial appendage occlusion: A critical appraisal updated with recent evidence

Abstract

All Science Journal Classification (ASJC) codes

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