Leptin: pathogenesis and treatment of morbid obesity.

A. Kumar, N. A. Inverso, C. D. Still

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Leptin is a hormone produced primarily by the adipocytes. It works through different receptors and seems to provide information to the hypothalamus about the energy status of the body. Although leptin appears to exert its anti-obesity effect through its central action, the full spectrum of its action is yet to be determined. Most obese subjects in studies have high serum levels of leptin, suggesting that the major problem is leptin resistance rather than leptin deficiency. Consequently, these patients may not respond to exogenous leptin. Recent trials have indicated, however, that leptin may have therapeutic potential in leptin-deficient as well as leptin-resistant states.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalCurrent gastroenterology reports
Issue number4
StatePublished - Aug 2000

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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