Lethal Mutagenesis: Exploiting Error-Prone Replication of Riboviruses for Antiviral Therapy

Jason D. Graci; Craig E. Cameron

doi:10.1002/0471716715.ch9

Lethal Mutagenesis: Exploiting Error-Prone Replication of Riboviruses for Antiviral Therapy

Jason D. Graci, Craig E. Cameron

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Replication of RNA viruses is an errorâprone process leading to approximately one mutation per genome per replication. However, there is a maximum level of mutation, termed the error threshold, beyond which the error frequency is too great to support viability. This chapter examines the evidence supporting lethal mutagenesis in vitro and in vivo. Additionally, the impact of resistance and the challenges to development of clinically effective lethal mutagens are discussed.

Original language	English (US)
Title of host publication	Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats
Publisher	John Wiley and Sons
Pages	203-220
Number of pages	18
ISBN (Print)	0471668273, 9780471668275
DOIs	https://doi.org/10.1002/0471716715.ch9
State	Published - Jan 27 2005

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1002/0471716715.ch9

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abstract = "Replication of RNA viruses is an error{\^a}prone process leading to approximately one mutation per genome per replication. However, there is a maximum level of mutation, termed the error threshold, beyond which the error frequency is too great to support viability. This chapter examines the evidence supporting lethal mutagenesis in vitro and in vivo. Additionally, the impact of resistance and the challenges to development of clinically effective lethal mutagens are discussed.",

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Lethal Mutagenesis: Exploiting Error-Prone Replication of Riboviruses for Antiviral Therapy

Abstract

All Science Journal Classification (ASJC) codes

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