Lethal mutagens: Broad-spectrum antivirals with limited potential for development of resistance?

Marion S. Freistadt, Glen D. Meades, Craig E. Cameron

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


RNA virus populations display extreme sequence variation. It is thought that this heterogeneity is advantageous to the population, permitting adaptation to rapidly changing environments that present varying types and degrees of selective pressure. A consequence of of this efficient evolution of RNA viruses is the susceptibility of these viruses to compounds that further increase sequence variation as these agents force the virus into error catastrophe. Therefore, lethal mutagenesis, induction of error catastrophe, represents an important, untapped strategy for development of antiviral agents. This article briefly describes the theoretical and experimental data supporting lethal mutagenesis as an antiviral strategy and discusses host and viral mechanisms for development of resistance to ribavirin, a representative of this class of antiviral agents.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalDrug Resistance Updates
Issue number1
StatePublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Cancer Research
  • Infectious Diseases
  • Pharmacology (medical)


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