Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

Wei Zhang; Xuexin Zhang; José C. González-Cobos; Judith A. Stolwijk; Khalid Matrougui; Mohamed Trebak

doi:10.1074/jbc.M114.625822

Leukotriene-C₄ synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

Wei Zhang, Xuexin Zhang, José C. González-Cobos, Judith A. Stolwijk, Khalid Matrougui, Mohamed Trebak

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Background: LTC₄S is required for Orai1/Orai3 LRC channel activation. However, the role of LTC₄S in neointimal hyperplasia is unknown. Results: LTC₄S knockdown inhibited neointimal hyperplasia. Akt phosphorylation was decreased in injured arteries, and knockdown of Orai3 or LTC₄S restored Akt phosphorylation. Conclusion: LTC4S is required for neointimal hyperplasia. Significance: LTC₄S is a potential therapeutic target for vascular occlusive diseases.

Original language	English (US)
Pages (from-to)	5015-5027
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	290
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M114.625822
State	Published - Feb 20 2015

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.625822

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title = "Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia",

abstract = "Background: LTC4S is required for Orai1/Orai3 LRC channel activation. However, the role of LTC4S in neointimal hyperplasia is unknown. Results: LTC4S knockdown inhibited neointimal hyperplasia. Akt phosphorylation was decreased in injured arteries, and knockdown of Orai3 or LTC4S restored Akt phosphorylation. Conclusion: LTC4S is required for neointimal hyperplasia. Significance: LTC4S is a potential therapeutic target for vascular occlusive diseases.",

author = "Wei Zhang and Xuexin Zhang and Gonz{\'a}lez-Cobos, {Jos{\'e} C.} and Stolwijk, {Judith A.} and Khalid Matrougui and Mohamed Trebak",

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doi = "10.1074/jbc.M114.625822",

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TY - JOUR

T1 - Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

AU - Zhang, Wei

AU - Zhang, Xuexin

AU - González-Cobos, José C.

AU - Stolwijk, Judith A.

AU - Matrougui, Khalid

AU - Trebak, Mohamed

PY - 2015/2/20

Y1 - 2015/2/20

N2 - Background: LTC4S is required for Orai1/Orai3 LRC channel activation. However, the role of LTC4S in neointimal hyperplasia is unknown. Results: LTC4S knockdown inhibited neointimal hyperplasia. Akt phosphorylation was decreased in injured arteries, and knockdown of Orai3 or LTC4S restored Akt phosphorylation. Conclusion: LTC4S is required for neointimal hyperplasia. Significance: LTC4S is a potential therapeutic target for vascular occlusive diseases.

AB - Background: LTC4S is required for Orai1/Orai3 LRC channel activation. However, the role of LTC4S in neointimal hyperplasia is unknown. Results: LTC4S knockdown inhibited neointimal hyperplasia. Akt phosphorylation was decreased in injured arteries, and knockdown of Orai3 or LTC4S restored Akt phosphorylation. Conclusion: LTC4S is required for neointimal hyperplasia. Significance: LTC4S is a potential therapeutic target for vascular occlusive diseases.

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Leukotriene-C₄ synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

Abstract

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