Leveraging Decision Science to Characterize Depression

This brief review examines the potential to use decision science to objectively characterize depression. We provide a brief overview of the existing literature examining different domains of decision-making in depression. Because this overview highlights the specific role of reinforcement learning as an important decision process affected in the disorder, we then introduce reinforcement learning modeling and explain how this approach has identified specific reinforcement learning deficits in depression. We conclude with ideas for future research at the intersection of decision science and depression, emphasizing the potential for decision science to help uncover underlying mechanisms and targets for the treatment of depression.