Abstract
We utilized evidence for enhancer-promoter interactions from functional genomics data in order to build biological filters to narrow down the search space for two-way Single Nucleotide Polymorphism (SNP) interactions in Type 2 Diabetes (T2D) Genome Wide Association Studies (GWAS). This has led us to the identification of a reproducible statistically significant SNP pair associated with T2D. As more functional genomics data are being generated that can help identify potentially interacting enhancer-promoter pairs in larger collection of tissues/cells, this approach has implications for investigation of epistasis from GWAS in general.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 548-558 |
| Number of pages | 11 |
| Journal | Pacific Symposium on Biocomputing |
| Volume | 0 |
| DOIs | |
| State | Published - 2018 |
| Event | 23rd Pacific Symposium on Biocomputing, PSB 2018 - Kohala Coast, United States Duration: Jan 3 2018 → Jan 7 2018 |
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Computational Theory and Mathematics
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