Levosimendan vs. intra-aortic balloon pump in high-risk cardiac surgery

Vladimir V. Lomivorotov, Alexander M. Cherniavskiy, Vladimir A. Boboshko, Igor A. Kornilov, Vladimir N. Lomivorotov, Alexander M. Karaskov

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The purpose of our study was to compare the efficiency of levosimendan and preventive intra-aortic balloon pump in high-risk cardiac patients (left ventricular ejection fraction <35%) operated under cardiopulmonary bypass. In 20 patients, intra-aortic balloon pump was started 16-18 h before surgery; another 20 had a levosimendan infusion starting after induction of anesthesia with an initial bolus of 12μgkg-1 for 10min, followed by 0.1 μgkg-1 min-1 for 24h. Postoperative complications, hemodynamics, and markers of cardiac damage were analyzed. In the levosimendan group, cardiac index was significantly higher 5 min after cardiopulmonary bypass, at the end of the operation, 2 and 4h after perfusion, compared to the intra-aortic balloon pump group. The level of troponin I in the levosimendan group was significantly lower at 6 h after the operation. Intensive care unit stay was significantly shorter in the levosimendan group. It was concluded that the use of levosimendan in high-risk cardiac patients is as effective as intra-aortic balloon pump, in terms of maintaining stable hemodynamic during and after operations under cardiopulmonary bypass. The lower level of troponin I at 6 h postoperatively suggests cardioprotective properties of levosimendan, but requires further investigation.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalAsian Cardiovascular and Thoracic Annals
Issue number2
StatePublished - Apr 2011

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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