@article{1c505556b940448ea8404937c0209696,
title = "Lexical-semantic search related to side of onset and putamen volume in Parkinson's disease",
abstract = "Parkinson's disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p < 0.05). PD-R age of acquisition responses correlated positively with putamen volume (p < 0.05), while age of acquisition of responses correlated negatively with caudate volume in controls (p < 0.05). Findings provide evidence for a role of the striatum in lexical-semantic access and qualitative changes in lexical access in select PD patients.",
author = "Daymond Wagner and Eslinger, {Paul J.} and Sterling, {Nicholas W.} and Guangwei Du and Lee, {Eun Young} and Martin Styner and Lewis, {Mechelle M.} and Xuemei Huang",
note = "Funding Information: This work was supported by the National Institute Neurological Disorders and Stroke (NS060722 and NS082151 to XH); Hershey Medical Center GCRC (National Center for Research Resources, Grant UL1 RR033184, now at the National Center for Advancing Translational Sciences, Grant UL1 TR000127); Pennsylvania Department of Health Tobacco CURE Funds, CTSI (TL1 TR000125); and the intramural research program of the National Institute of Health and the National Institute of Environmental Health Sciences. We wish to thank our support staff for their assistance in data collection. We also wish to thank our participants and their families for the contribution of their time and effort. Funding Information: This work was supported by the National Institute Neurological Disorders and Stroke ( NS060722 and NS082151 to XH); Hershey Medical Center GCRC ( National Center for Research Resources, Grant UL1 RR033184 , now at the National Center for Advancing Translational Sciences, Grant UL1 TR000127) ; Pennsylvania Department of Health Tobacco CURE Funds , CTSI (TL1 TR000125); and the intramural research program of the National Institute of Health and the National Institute of Environmental Health Sciences. We wish to thank our support staff for their assistance in data collection. We also wish to thank our participants and their families for the contribution of their time and effort. Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = oct,
doi = "10.1016/j.bandl.2020.104841",
language = "English (US)",
volume = "209",
journal = "Brain and Language",
issn = "0093-934X",
publisher = "Academic Press Inc.",
}