TY - JOUR
T1 - Life-style risk factors for pancreatic cancer in louisiana
T2 - A case-control study
AU - Falk, Roni T.
AU - Williams Pickle, Linda
AU - Fontham, Elizabeth T.
AU - Correa, Pelayo
AU - Fraumeni, Joseph F.
N1 - Funding Information:
The project in southern Louisiana was supported by contract no. N01-CP-91023 from the National Cancer Institute. Work in northern Louisiana was supported by a grant from the Louisiana Division of the American Cancer Society.
PY - 1988/8
Y1 - 1988/8
N2 - A hospital-based, incident case-control study of pancreatic cancer was con ducted between 1979 and 1983 in parallel with similarly designed studies of lung and stomach cancers in high-risk areas of Louisiana. To evaluate life-style practices, including diet, the authors pooled controls from the three studies, and then excluded subjects with diet-altering chronic diseases. When the 363 cases were compared with the 1,234 identified controls, significantly elevated risks were found among persons with Cajun ancestry, especially in rural areas. Among current smokers, a significant twofold risk was associated with moderate (16-25 cigarettes per day) and heavy (≥26 cigarettes per day) consumption, while ex-smokers showed no consistent pattern of risk. After adjustment for potential confounding by smoking, diet, and demographic factors, the risk of pancreatic cancer was unrelated to use of alcoholic beverages or coffee. Pork products and rice were conspicuous as dietary risk factors, each showing a positive dose-response effect, whereas fruit consumption exerted a protective influence.
AB - A hospital-based, incident case-control study of pancreatic cancer was con ducted between 1979 and 1983 in parallel with similarly designed studies of lung and stomach cancers in high-risk areas of Louisiana. To evaluate life-style practices, including diet, the authors pooled controls from the three studies, and then excluded subjects with diet-altering chronic diseases. When the 363 cases were compared with the 1,234 identified controls, significantly elevated risks were found among persons with Cajun ancestry, especially in rural areas. Among current smokers, a significant twofold risk was associated with moderate (16-25 cigarettes per day) and heavy (≥26 cigarettes per day) consumption, while ex-smokers showed no consistent pattern of risk. After adjustment for potential confounding by smoking, diet, and demographic factors, the risk of pancreatic cancer was unrelated to use of alcoholic beverages or coffee. Pork products and rice were conspicuous as dietary risk factors, each showing a positive dose-response effect, whereas fruit consumption exerted a protective influence.
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U2 - 10.1093/oxfordjournals.aje.a114972
DO - 10.1093/oxfordjournals.aje.a114972
M3 - Article
C2 - 3394699
AN - SCOPUS:0023807240
SN - 0002-9262
VL - 128
SP - 324
EP - 336
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 2
ER -