Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator

Chi Wang, Andrei A. Aleksandrov, Zhengrong Yang, Farhad Forouhar, Elizabeth A. Proctor, Pradeep Kota, Jianli An, Anna Kaplan, Netaly Khazanov, Grégory Boël, Brent R. Stockwell, Hanoch Senderowitz, Nikolay V. Dokholyan, John R. Riordan, Christie G. Brouillette, John F. Hunt

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Biochemistry, Genetics and Molecular Biology