Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Kalyn A. Brown; Yan Zou; David Shirvanyants; Jie Zhang; Subhas Samanta; Pavan K. Mantravadi; Nikolay V. Dokholyan; Alexander Deiters

doi:10.1039/c4cc09442e

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Kalyn A. Brown, Yan Zou, David Shirvanyants, Jie Zhang, Subhas Samanta, Pavan K. Mantravadi, Nikolay V. Dokholyan, Alexander Deiters

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function. This journal is

Original language	English (US)
Pages (from-to)	5702-5705
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	26
DOIs	https://doi.org/10.1039/c4cc09442e
State	Published - Apr 4 2015

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c4cc09442e

Cite this

@article{8be711a0de2949be80af260a6f56ff40,

title = "Light-cleavable rapamycin dimer as an optical trigger for protein dimerization",

abstract = "Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function. This journal is",

author = "Brown, {Kalyn A.} and Yan Zou and David Shirvanyants and Jie Zhang and Subhas Samanta and Mantravadi, {Pavan K.} and Dokholyan, {Nikolay V.} and Alexander Deiters",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

month = apr,

day = "4",

doi = "10.1039/c4cc09442e",

language = "English (US)",

volume = "51",

pages = "5702--5705",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "26",

}

TY - JOUR

T1 - Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

AU - Brown, Kalyn A.

AU - Zou, Yan

AU - Shirvanyants, David

AU - Zhang, Jie

AU - Samanta, Subhas

AU - Mantravadi, Pavan K.

AU - Dokholyan, Nikolay V.

AU - Deiters, Alexander

PY - 2015/4/4

Y1 - 2015/4/4

N2 - Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function. This journal is

AB - Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84925339790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925339790&partnerID=8YFLogxK

U2 - 10.1039/c4cc09442e

DO - 10.1039/c4cc09442e

M3 - Article

C2 - 25716548

AN - SCOPUS:84925339790

SN - 1359-7345

VL - 51

SP - 5702

EP - 5705

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this