Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Kalyn A. Brown; Yan Zou; David Shirvanyants; Jie Zhang; Subhas Samanta; Pavan K. Mantravadi; Nikolay V. Dokholyan; Alexander Deiters

doi:10.1039/c4cc09442e

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Kalyn A. Brown
, Yan Zou
, David Shirvanyants
, Jie Zhang
, Subhas Samanta
, Pavan K. Mantravadi
, Nikolay V. Dokholyan
, Alexander Deiters

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.

Original language	English (US)
Pages (from-to)	5702-5705
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	26
DOIs	https://doi.org/10.1039/c4cc09442e
State	Published - Apr 4 2015

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c4cc09442e

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title = "Light-cleavable rapamycin dimer as an optical trigger for protein dimerization",

abstract = "Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.",

author = "Brown, \{Kalyn A.\} and Yan Zou and David Shirvanyants and Jie Zhang and Subhas Samanta and Mantravadi, \{Pavan K.\} and Dokholyan, \{Nikolay V.\} and Alexander Deiters",

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T1 - Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

AU - Brown, Kalyn A.

AU - Zou, Yan

AU - Shirvanyants, David

AU - Zhang, Jie

AU - Samanta, Subhas

AU - Mantravadi, Pavan K.

AU - Dokholyan, Nikolay V.

AU - Deiters, Alexander

PY - 2015/4/4

Y1 - 2015/4/4

N2 - Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.

AB - Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.

UR - https://www.scopus.com/pages/publications/84925339790

UR - https://www.scopus.com/pages/publications/84925339790#tab=citedBy

U2 - 10.1039/c4cc09442e

DO - 10.1039/c4cc09442e

M3 - Article

C2 - 25716548

AN - SCOPUS:84925339790

SN - 1359-7345

VL - 51

SP - 5702

EP - 5705

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Abstract

All Science Journal Classification (ASJC) codes

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