Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2

Rebecca Elsaesser, Deepak Kalra, Ruoxia Li, Craig Montell

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Photoreceptor cells are remarkable in their ability to adjust their sensitivity to lightover a widerangeof intensities. Rapid termination of the photoresponse is achieved in part by shuttling proteins in and out of the light-transducing compartment of the photoreceptor cells. One protein that undergoes light-dependent translocation is the rhodopsin regulatory protein arrestin. However, the mechanisms coupling rhodopsin to arrestin movement are poorly understood. Hereweshowthat light-dependent shuttling of the major arrestin in Drosophila photoreceptor cells, Arrestin2 (Arr2), occurs independently of known elements of the phototransduction cascade. Disruptions of the trimeric G protein, phospholipase Cβ, the TRP channel, or the Na +/Ca2+ exchanger did not influence Arr2 localization. Rather, we found that loss of the small GTPase Rac2 severely impaired Arr2 movement and prolonged the termination of the photoresponse. Our findings demonstrate that light-induced translocation of Arr2 occurs through a noncanonical rhodopsin/Rac2 pathway, which is distinct from the classical phototransduction cascade.

Original languageEnglish (US)
Pages (from-to)4740-4745
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number10
StatePublished - Mar 9 2010

All Science Journal Classification (ASJC) codes

  • General


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