Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency

Ajay Bhala; Michael J. Bennett; Karin L. McGowan; Daniel E. Hale

doi:10.1016/S0022-3476(05)83499-7

Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency

Ajay Bhala, Michael J. Bennett, Karin L. McGowan, Daniel E. Hale

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylproplonylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.

Original language	English (US)
Pages (from-to)	100-103
Number of pages	4
Journal	The Journal of Pediatrics
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(05)83499-7
State	Published - Jan 1993

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(05)83499-7

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title = "Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency",

abstract = "Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylproplonylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.",

author = "Ajay Bhala and Bennett, {Michael J.} and McGowan, {Karin L.} and Hale, {Daniel E.}",

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AU - Bennett, Michael J.

AU - McGowan, Karin L.

AU - Hale, Daniel E.

PY - 1993/1

Y1 - 1993/1

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AB - Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylproplonylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.

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Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency

Abstract

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