Abstract
Chronic constipation and irritable bowel syndrome (IBS) are functional gastrointestinal disorders that significantly affect patients' quality of life. Chronic constipation and IBS are prevalent-12% of the US population meet the diagnostic criteria for IBS, and 15% meet the criteria for chronic constipation- and these conditions negatively impact the healthcare system from an economic perspective. Despite attempts at dietary modification, exercise, or use of over-the-counter medications, many patients have persistent symptoms. Alternative treatment options are limited. This article describes linaclotide (Linzess, Ironwood Pharmaceuticals/Forest Pharmaceuticals), a new, firstin- class medication for the treatment of chronic constipation and constipation-predominant IBS.
Original language | English (US) |
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Pages (from-to) | 653-660 |
Number of pages | 8 |
Journal | Gastroenterology and Hepatology |
Volume | 8 |
Issue number | 10 |
State | Published - Oct 2012 |
All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology