Abstract
Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-96 |
| Number of pages | 12 |
| Journal | Genetical research |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2002 |
All Science Journal Classification (ASJC) codes
- Genetics