Linkage mapping of sex-specific differences

Rongling Wu, Chang Xing Ma, S. S. Wu, Zhao Bang Zeng

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.

Original languageEnglish (US)
Pages (from-to)85-96
Number of pages12
JournalGenetical research
Issue number1
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Genetics


Dive into the research topics of 'Linkage mapping of sex-specific differences'. Together they form a unique fingerprint.

Cite this