Lipid Feeding and Milk Fat Depression

Thomas C. Jenkins, Kevin J. Harvatine

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Diets fed to cattle contain mostly unsaturated fatty acids supplied in grains and forages, by-products, and fat supplements. Lipid intake by dairy cattle must be restricted to prevent alterations of microbial populations in the rumen that can negatively affect milk yield. Unsaturated fatty acids consumed by cattle are extensively metabolized through biohydrogenation, intermediates of which include conjugated linoleic acid (CLA) and trans-monoenoic acid isomers. Three specific CLA intermediates of biohydrogenation have been shown to cause milk fat depression in dairy cattle through coordinated suppression of mammary lipogenic genes by a transcription factor that is a central regulator of lipid synthesis.

Original languageEnglish (US)
Pages (from-to)623-642
Number of pages20
JournalVeterinary Clinics of North America - Food Animal Practice
Issue number3
StatePublished - Nov 1 2014

All Science Journal Classification (ASJC) codes

  • Food Animals


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