@article{86f63102234a4c5fb4b6281722e34f3d,
title = "Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles",
abstract = "Amphiphilic Janus particles self-assemble into complex metastructures, but little is known about how their assembly might be modified by weak interactions with a nearby biological membrane surface. Here, we report an integrated experimental and molecular dynamics simulation study to investigate the self-assembly of amphiphilic Janus particles on a lipid membrane. We created an experimental system in which Janus particles are allowed to self-assemble in the same medium where zwitterionic lipids form giant unilamellar vesicles (GUVs). Janus particles spontaneously concentrated on the inner leaflet of the GUVs. They exhibited biased orientation and heterogeneous rotational dynamics as revealed by single particle rotational tracking. The combined experimental and simulation results show that Janus particles concentrate on the lipid membranes due to weak particle-lipid attraction, whereas the biased orientation of particles is driven predominantly by inter-particle interactions. This study demonstrates the potential of using lipid membranes to influence the self-assembly of Janus particles.",
author = "Mariah Chambers and Mallory, {Stewart Anthony} and Heather Malone and Yuan Gao and Anthony, {Stephen M.} and Yi Yi and Angelo Cacciuto and Yan Yu",
note = "Funding Information: The authors gratefully acknowledge the assistance of Dr Jim Powers with fluorescence imaging at the IUB Light Microscopy Imaging Center. Fabrication of Janus particles was performed at the Nanoscale Characterization Facility at Indiana University. This work was supported by the National Science Foundation under Grant No. CBET-1554078 to Y. Y. and Grant No. DMR-1408259 to A. C. S. A. M acknowledges financial support from the National Science Foundation Graduate Research Fellowship grant number DGE-1144155. S. M. A. acknowledges support from the Sandia National Laboratories. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by the National Science Foundation under Grant No. ACI-1053575. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2016",
doi = "10.1039/c6sm02171a",
language = "English (US)",
volume = "12",
pages = "9151--9157",
journal = "Soft matter",
issn = "1744-683X",
publisher = "Royal Society of Chemistry",
number = "45",
}