TY - JOUR
T1 - Liquid biopsy in central nervous system metastases
T2 - A RANO review and proposals for clinical applications
AU - Boire, Adrienne
AU - Brandsma, Dieta
AU - Brastianos, Priscilla K.
AU - Le Rhun, Emilie
AU - Ahluwalia, Manmeet
AU - Junck, Larry
AU - Glantz, Michael
AU - Groves, Morris D.
AU - Lee, Eudocia Q.
AU - Lin, Nancy
AU - Raizer, Jeffrey
AU - Rudà, Roberta
AU - Weller, Michael
AU - Van Den Bent, Martin J.
AU - Vogelbaum, Michael A.
AU - Chang, Susan
AU - Wen, Patrick Y.
AU - Soffietti, Riccardo
N1 - Publisher Copyright:
© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.
AB - Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.
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U2 - 10.1093/neuonc/noz012
DO - 10.1093/neuonc/noz012
M3 - Review article
C2 - 30668804
AN - SCOPUS:85065640489
SN - 1522-8517
VL - 21
SP - 571
EP - 583
JO - Neuro-oncology
JF - Neuro-oncology
IS - 5
ER -