@article{13ff200b58964ba5b9c1567159ca6149,
title = "Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication",
abstract = "The leap of retroviruses and coronaviruses from animal hosts to humans has led to two ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus nucleocapsid proteins have been studied extensively as potential drug targets due to their central roles in virus replication, among which is their capacity to bind their respective genomic RNAs for packaging into nascent virions. This review focuses on fundamental studies of these nucleocapsid proteins and how their intrinsic abilities to condense through liquid-liquid phase separation (LLPS) contribute to viral replication. Therapeutic targeting of these condensates and methodological advances are also described to address future questions on how phase separation contributes to viral replication.",
author = "Chau, {Bao An} and Venessa Chen and Cochrane, {Alan W.} and Parent, {Leslie J.} and Mouland, {Andrew J.}",
note = "Funding Information: The authors apologize to authors of publications that were not included in this review due to space constraints. This work was funded by grants from the Canadian Institutes of Health Research ( FRN-162447 to A.J.M. and PJT- 178165 to A.W.C.), the National Institutes of Health ( R21DA053689 to L.J.P. and a subcontract to A.J.M.), and a COVID-19 Innovation Fund Award (to L.J.P.) from Penn State College of Medicine , Department of Medicine. Funding Information: The authors apologize to authors of publications that were not included in this review due to space constraints. This work was funded by grants from the Canadian Institutes of Health Research (FRN-162447 to A.J.M. and PJT-178165 to A.W.C.), the National Institutes of Health (R21DA053689 to L.J.P. and a subcontract to A.J.M.), and a COVID-19 Innovation Fund Award (to L.J.P.) from Penn State College of Medicine, Department of Medicine. A.J.M. conceived of the content and organization of this review. B.-A.C. and V.C. contributed equally to the composition and preparation of this review. All authors drafted, prepared figures, revised, and approved the final version of this manuscript; A.W.C. L.J.P. and A.J.M. secured funding. All authors do not have any conflicts of interest. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2023",
month = jan,
day = "31",
doi = "10.1016/j.celrep.2022.111968",
language = "English (US)",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}