Lithium-induced increase in human brain grey matter

Gregory J. Moore; Joseph M. Bebchuk; Ian B. Wilds; Guang Chen; Husseini K. Menji

doi:10.1016/S0140-6736(00)02793-8

Lithium-induced increase in human brain grey matter

Gregory J. Moore
, Joseph M. Bebchuk
, Ian B. Wilds
, Guang Chen
, Husseini K. Menji

Research output: Contribution to journal › Article › peer-review

587 Scopus citations

Abstract

Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.

Original language	English (US)
Pages (from-to)	1241-1242
Number of pages	2
Journal	Lancet
Volume	356
Issue number	9237
DOIs	https://doi.org/10.1016/S0140-6736(00)02793-8
State	Published - Oct 7 2000

All Science Journal Classification (ASJC) codes

General Medicine

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10.1016/S0140-6736(00)02793-8

Cite this

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title = "Lithium-induced increase in human brain grey matter",

abstract = "Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.",

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AU - Moore, Gregory J.

AU - Bebchuk, Joseph M.

AU - Wilds, Ian B.

AU - Chen, Guang

AU - Menji, Husseini K.

PY - 2000/10/7

Y1 - 2000/10/7

N2 - Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.

AB - Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.

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UR - https://www.scopus.com/pages/publications/0034619037#tab=citedBy

U2 - 10.1016/S0140-6736(00)02793-8

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SP - 1241

EP - 1242

JO - Lancet

JF - Lancet

IS - 9237

ER -

Lithium-induced increase in human brain grey matter

Abstract

All Science Journal Classification (ASJC) codes

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