Liver as a source of transformed cell growth factor

Elizabeth Witkoski; Mary F. Schuler; Richard C. Feldhoff; Samson I. Jacob; Leonard S. Jefferson; Allan Lipton

doi:10.1016/0014-4827(79)90202-7

Liver as a source of transformed cell growth factor

Elizabeth Witkoski, Mary F. Schuler, Richard C. Feldhoff, Samson I. Jacob, Leonard S. Jefferson, Allan Lipton

Research output: Contribution to journal › Article › peer-review

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Abstract

Isolated rat hepatocytes release an acidic glycoprotein(s) that can selectively promote the growth of transformed cells. This factor has a molecular weight of 60 000-70 000 D. Liver microsomal and cytosol fractions contain two species of stimulatory activity-44 000 and 3 500 D. Mitochondrial and nuclear fractions contain only the lower molecular weight factor.

Original language	English (US)
Pages (from-to)	261-267
Number of pages	7
Journal	Experimental Cell Research
Volume	124
Issue number	2
DOIs	https://doi.org/10.1016/0014-4827(79)90202-7
State	Published - Dec 1979

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1016/0014-4827(79)90202-7

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title = "Liver as a source of transformed cell growth factor",

abstract = "Isolated rat hepatocytes release an acidic glycoprotein(s) that can selectively promote the growth of transformed cells. This factor has a molecular weight of 60 000-70 000 D. Liver microsomal and cytosol fractions contain two species of stimulatory activity-44 000 and 3 500 D. Mitochondrial and nuclear fractions contain only the lower molecular weight factor.",

author = "Elizabeth Witkoski and Schuler, {Mary F.} and Feldhoff, {Richard C.} and Jacob, {Samson I.} and Jefferson, {Leonard S.} and Allan Lipton",

note = "Funding Information: This investigation was supported by USPHS Research Center CA 15858,A M 13499,a nd AM 15658, CA18450.",

year = "1979",

month = dec,

doi = "10.1016/0014-4827(79)90202-7",

language = "English (US)",

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pages = "261--267",

journal = "Experimental Cell Research",

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T1 - Liver as a source of transformed cell growth factor

AU - Witkoski, Elizabeth

AU - Schuler, Mary F.

AU - Feldhoff, Richard C.

AU - Jacob, Samson I.

AU - Jefferson, Leonard S.

AU - Lipton, Allan

N1 - Funding Information: This investigation was supported by USPHS Research Center CA 15858,A M 13499,a nd AM 15658, CA18450.

PY - 1979/12

Y1 - 1979/12

N2 - Isolated rat hepatocytes release an acidic glycoprotein(s) that can selectively promote the growth of transformed cells. This factor has a molecular weight of 60 000-70 000 D. Liver microsomal and cytosol fractions contain two species of stimulatory activity-44 000 and 3 500 D. Mitochondrial and nuclear fractions contain only the lower molecular weight factor.

AB - Isolated rat hepatocytes release an acidic glycoprotein(s) that can selectively promote the growth of transformed cells. This factor has a molecular weight of 60 000-70 000 D. Liver microsomal and cytosol fractions contain two species of stimulatory activity-44 000 and 3 500 D. Mitochondrial and nuclear fractions contain only the lower molecular weight factor.

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JF - Experimental Cell Research

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ER -

Liver as a source of transformed cell growth factor

Abstract

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