Liver as a source of transformed cell growth factor

Elizabeth Witkoski, Mary F. Schuler, Richard C. Feldhoff, Samson I. Jacob, Leonard S. Jefferson, Allan Lipton

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Isolated rat hepatocytes release an acidic glycoprotein(s) that can selectively promote the growth of transformed cells. This factor has a molecular weight of 60 000-70 000 D. Liver microsomal and cytosol fractions contain two species of stimulatory activity-44 000 and 3 500 D. Mitochondrial and nuclear fractions contain only the lower molecular weight factor.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalExperimental Cell Research
Issue number2
StatePublished - Dec 1979

All Science Journal Classification (ASJC) codes

  • Cell Biology


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