TY - JOUR
T1 - Living in the endosymbiotic world of Wolbachia
T2 - A centennial review
AU - Kaur, Rupinder
AU - Shropshire, J. Dylan
AU - Cross, Karissa L.
AU - Leigh, Brittany
AU - Mansueto, Alexander J.
AU - Stewart, Victoria
AU - Bordenstein, Sarah R.
AU - Bordenstein, Seth R.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/6/9
Y1 - 2021/6/9
N2 - The most widespread intracellular bacteria in the animal kingdom are maternally inherited endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes worldwide and stunning arsenal of parasitic and mutualistic adaptations make these bacteria a biological archetype for basic studies of symbiosis and applied outcomes for curbing human and agricultural diseases. Here, we conduct a summative, centennial analysis of living in the Wolbachia world. We synthesize literature on Wolbachia's host range, phylogenetic diversity, genomics, cell biology, and applications to filarial, arboviral, and agricultural diseases. We also review the mobilome of Wolbachia including phage WO and its essentiality to hallmark reproductive phenotypes in arthropods. Finally, the Wolbachia system is an exemplar for discovery-based science education using biodiversity, biotechnology, and bioinformatics lessons. As we approach a century of Wolbachia research, the interdisciplinary science of this symbiosis stands as a model for consolidating and teaching the integrative rules of endosymbiotic life.
AB - The most widespread intracellular bacteria in the animal kingdom are maternally inherited endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes worldwide and stunning arsenal of parasitic and mutualistic adaptations make these bacteria a biological archetype for basic studies of symbiosis and applied outcomes for curbing human and agricultural diseases. Here, we conduct a summative, centennial analysis of living in the Wolbachia world. We synthesize literature on Wolbachia's host range, phylogenetic diversity, genomics, cell biology, and applications to filarial, arboviral, and agricultural diseases. We also review the mobilome of Wolbachia including phage WO and its essentiality to hallmark reproductive phenotypes in arthropods. Finally, the Wolbachia system is an exemplar for discovery-based science education using biodiversity, biotechnology, and bioinformatics lessons. As we approach a century of Wolbachia research, the interdisciplinary science of this symbiosis stands as a model for consolidating and teaching the integrative rules of endosymbiotic life.
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U2 - 10.1016/j.chom.2021.03.006
DO - 10.1016/j.chom.2021.03.006
M3 - Review article
C2 - 33945798
AN - SCOPUS:85108124188
SN - 1931-3128
VL - 29
SP - 879
EP - 893
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 6
ER -